Genetic variants help uncover potential new treatment pathway in kidney cancer

Investigators have found that inhibition of the purine salvage pathway in hereditary leiomyomatosis and renal cell cancer (HLRCC) tumors reduced growth of the tumors in vivo, signaling a possible new treatment strategy for patients with kidney cancer, according to findings published in Cancer Discovery.

The targeting of this pathway is based on the study findings that a number of genetic variants previously of unknown significance rely on the purine salvage pathway for growth, and they predispose patients to HLRCC, which increases the risk of developing aggressive kidney cancer.

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